Learning Objectives

• Describe the cellular changes that occur in response to nerve injury
• Describe the steps in the process of peripheral nerve repair
• Describe the aetiology and incidence of Alzheimer’s disease
• Describe the pathophysiology of Alzheimer’s disease
• Outline the basic pathophysiology of epilepsy
• Describe the seizure types associated with different forms of epilepsy

Nerve Injury

• what are some common causes of nerve injury?
• most injuries to nerves involves damage to [structural component]?
• how does the CNS vs PNS compare in regrowth ability?
• types of nerve injuries according to Seddon’s classification?
• types of nerve injuries according to Sunderland’s classification?
• what is the mechanism of denervation supersensitivity?

Nerve Degeneration

• what is anterograde (Wallerian) degeneration?
• what is the mechanism of anterograde degeneration?
• what is retrograde degeneration?
• what is the mechanism of retrograde degeneration?