Learning Objectives
- Outline the typical cellular immune response to cancer,
including the role of T cells and tumour antigens
- Provide example of mechanisms responsible for suboptimal immunity against tumour cells
- Summarise the major approaches to cancer immunotherapy, including non-specific immune stimulation, antibody therapies, immune checkpoint inhibitors, adoptive T-cell transfer therapies and therapeutic cancer 'vaccines'
- Highlight the current successes in cancer immunotherapy and future challenges
Cancer Immunity Cycle
- what are the 7 steps of the cancer immunity cycle?
- how do tumours evade the immune system?
- name some inhibitory factors against cancer immunity?
- what are 4 important mediators of anti-tumour immunity?
- how do APCs activate anti-tumour CTLs?
- what role do Abs have in anti-tumour immunity?
- what role do macrophages have in anti-tumour immunity?
- how do tumours affect macrophages?
Cancer Immunotherapy
- what are 3 types of non-specific immune stimulators?
- what are 2 types of anti-tumour Ab therapies?
- how is the immune response normally regulated?
- how do tumours interfere with this?