Learning Objectives

• Outline the pathophysiological mechanisms and processes responsible for the development of asthma, COPD and cystic fibrosis
• Identify the potential targets for drugs to interact with respiratory function and airway inflammation in respiratory disorders
• Describe the cellular mechanism of action of beta-2 agonists, anticholinergics, inhaled corticosteroids, leukotriene receptor antagonists and antibody therapies
• Explain the rationale for the therapeutic use for each of these drug classes in the treatment of asthma and COPD
• Describe the cellular mechanism of action of mucolytics and CFTR modulators in the treatment of cystic fibrosis
• Describe the cellular mechanism of action of antihistamines in the treatment of allergic rhinitis
• Outline the mechanisms of action, and indications for the use of cough suppressants
• Explain the major adverse effects and important interactions and contraindications associated with respiratory drug classes
• Outline the main current therapeutic approaches to pharmacotherapy for asthma, COPD and cystic fibrosis
• Outline the different delivery methods used to administer respiratory drugs

Asthma Management

• how should asthma management be approached?

Beta-2 Receptor Agonists

• indications?
• mechanism of action?
• administration?
• adverse effects?

Muscarinic Receptor Antagonists