Learning Objectives

• Understand the general principles of autoimmunity
• Understand basic mechanisms of pathogenesis of autoimmune diseases
• Provide examples of how T cells and autoAb drive autoimmune diseases
• Uderstand the basic principles of pathogenesis and diagnosis of RA, SLE (Lupus), RHD, and MS

Autoimmune Disease

• what is autoimmunity?
• what triggers autoimmunity?
• what gender do autoimmune diseases most commonly affect?
• autoimmunity can be any type of HS reaction except [type]?
• name some localised vs systemic autoimmune diseases?
• what is the link between autoimmunity and the MHC?
• [lymphocytes] play a central role in autoimmune responses?
• what are the mechanisms of central vs peripheral tolerance?
• what is the aim of treatment for autoimmune diseases?

Pathogenic Mechanisms of Autoimmunity

• what are 2 mechanisms of exposure of hidden epitopes?
• what are 4 mechanisms of exposure to infectious agents?
• what does molecular mimicry mean?