Learning Objectives

• Summarise the physiologic target organ responses and the mechanism of ADH secretion
• Describe how osmolality of ECF is maintained by alterations in vasopressin secretion
• Explain the causes and consequences of excess and deficiency of ADH secretion
• Describe the main features of the diabetes insipidus
• Explain the roles of anti-diuretic hormone, aldosterone, angiotensin II and atrial natriuretic peptide in the regulation of plasma sodium levels
• Explain the hormonal regulation of plasma potassium

ADH

• where is ADH synthesised?
• compare osmoreceptors vs baroreceptors?
• stimulating factors?
• inhibiting factors?
• which factors directly affect ADH secretion?
• list all of the ADH receptors?
• action/ function?

Renin Angiotensin Aldosterone System

• what cells secrete renin?
• stimulating factors?
• inhibiting factors?