Learning Objectives

• What are the effects of diuretics have on Na+ handling by the kidneys?
• Why do diuretics decrease the volume of the extracellular fluid?
• What is the primary nephron site where each class of diuretics act, and what is the specific membrane transport protein affected?
• How do nephrons alter their function in response to diuretics, and how does this affect the action of diuretics?
• What is renal failure?
• List some of the causes for acute renal failure

Loop Diuretics

• site of action?
• mechanism of action?
• clinical uses?
• potency?
• side effects?

Thiazide Diuretics

• site of action?
• mechanism of action?
• clinical uses?
• potency?
• side effects?