Learning Objectives

• Know how fat metabolism is regulated in the adipose tissue and liver
• Know how fats are broken down (beta oxidation) and transported around the body
• Know what happens to glycerol from the triglyceride
• Be able to calculate how many ATPs can be generated from of a triglyceride
• Know how and where ketone bodies are synthesized, transported and metabolised
• Know the importance of specific vitamins in the breakdown of odd-numbered fatty acids
• Know where NADPH comes from for fatty acid synthesis
• Know the first commitment step of fatty acid synthesis
• Comprehend the integration of sugar and fat metabolism

Fat Breakdown

• what is lipolysis?
• how are FAs transported into mitochondria?
• what is β-oxidation?
• what are the steps of β-oxidation?
• if there are insufficient substrates in the TCA cycle, what happens to acetyl CoA?
• what factors regulate β-oxidation?
• how is oxidation of odd-numbered FAs different?
• what dietary precautions should be taken in an individual with biotin deficiency?