Learning Objectives

• Identify the types of lipids in the body and describe their function (review)
• Describe the role of the liver in lipid metabolism
• List the classes of plasma lipoproteins and describe their structural components, including the roles of apolipoproteins and their receptors
• List the different types of lipoproteins and explain the functional role that each type plays in lipid transport
• Explain the role of lipids (especially LDL and HDL) in the pathogenesis of atherosclerosis
• Describe the factors and mechanisms that regulate plasma cholesterol concentration
• Describe the aetiology, pathophysiology and treatment of major dyslipidemias
• Relate the mechanism of action of drugs used for dyslipidemia to lipid transport processes
• Discuss the aetiology, pathophysiology and treatment of gallstones

Lipids

• what is the function of triglycerides?
• what is the function of phospholipids?
• what are the functions of cholesterol?
• what is exogenous vs endogenous cholesterol?

Lipid Transport & Lipoproteins

• why is a lipid transport system needed?
• describe the structure of a lipoprotein?
• what are apolipoproteins?