Learning Objectives

• Describe the cellular processes involved in penile erection
• Explain the mechanism of action of PDE-5 inhibitors in the treatment of erectile dysfunction
• Outline the processes, mediators and receptors involved in bladder filling and micturition reflexes
• Describe the pathophysiological mechanisms responsible for overactive bladder, urge incontinence and bladder outlet obstruction / benign prostatic hyperplasia
• Describe the mechanisms of action of anticholinergics and selective alpha-blockers on bladder function and relate this to their role in treatment
• Describe the mechanism of action of 5-alpha-reductase inhibitors in the treatment of BPH and BOO
• Describe the major mechanism of action of combined oral contraceptive drugs
• Outline the rationale for the effective use of drug treatment for menopause hormone therapy and discuss the risks and benefits of MHT
• Outline the major adverse effects, precautions and interactions associated with the classes of drugs described this week
• Resources

PDE-5 Inhibitors

• mechanism of action?
• indications?
• major adverse effects?
• important contraindications?
• important precautions?
• PDE Isoforms

Anticholinergics (Genitourinary Selective)