07 Gastrointestinal Drugs

Outline the basic pathophysiology of upper GI disorders including dyspepsia, peptic ulcer disease and GORD
Describe the normal physiological regulation of gastric acid secretion, including the cells, neurotransmitters, hormones, receptors and transporters involved
Explain the role of H Pylori and NSAIDs in development of ulcer disease
Describe the mechanisms of action and common adverse effects of the main drug classes used to suppress gastric acid secretion
Identify the CNS centres, processes and neurotransmitters involved in regulation of nausea and vomiting
Describe the mechanisms of action, common adverse effects, key drug interactions and precautions for the main drug classes used to treat nausea and vomiting
Outline the use of anti-emetic drug classes in the treatment of nausea and vomiting from different causes
Describe the mechanisms of action of drugs and major adverse effects of drugs used to treat constipation and diarrhoea
Describe the mechanisms of action of major adverse effects of orlistat, phentermine, and GLP-1 analogues in the treatment of obesity