06 Hallmarks of Cancer I

List the 8 hallmarks and the 2 enabling characteristics of cancer, and illustrate each with specific examples
Describe the different molecular mechanisms and major mutations which enable cancer cells to sustain proliferative signalling
Describe the different molecular mechanisms and major mutations which enable cancer cells to evade growth suppressors and resist cell death
Explain the role of telomerase in enabling replicative immortality
Describe the role of growth factors in promoting tumour angiogenesis
Outline the processes involved, and provide examples of mutations which enable tumour cells to invade and metastasize
Explain the alterations in energy metabolism that occur in cancer cells
Describe how cancer cells are able to evade the host immune response
Describe how inherited mutations in DNA repair proteins allow for genomic instability, and outline the stem cell theory of carcinogenesis
Describe how chronic inflammation contributes to systemic symptoms of cancer and also promotes cancer progression
Relate knowledge of the hallmarks to current and potential therapies for cancer