Learning Objectives
- Outline the normal physiological processes involved in hemostasis and thrombosis, including platelet activation and aggregation, and the coagulation cascade (review)
- Describe the role of arterial and venous thrombi in ischemic heart disease, stroke and pulmonary embolism (review)
- Explain the cellular mechanism of action of the different classes of anticoagulants, thrombolytics and antiplatelet drugs
- Describe the major adverse effects, contraindications and important diet/drug interactions associated with anticoagulants, thrombolytics and antiplatelet drugs
- Explain the importance of drug monitoring when using warfarin, and outline the role of the INR in patient management
- Outline the therapeutic rationale for the use of these drugs in the treatment and prevention of acute coronary syndromes, stroke, transient ischemia attack and venous thromboembolism
- Name the other classes of drugs used in the general management of acute coronary syndrome(myocardial infarction and unstable angina)
Hemostasis & Thrombosis
- what is hemostasis?
- what is thrombosis?
- why is thrombosis a problem?
- compare arterial vs venous thrombosis?
- what is Virchow’s Triad?
Aspirin
- mechanism of action?
- indications?
- major adverse effects?
- precautions?