Learning Objectives
- Examine the F1 generation of a hybrid cross and interpret what parental genes are involved
- Define Mendel’s Second Law: Independent Assortment and describe its relevance
- Outline the concept of linkage and how it affects Mendel’s Second Law
- Determine if a disease is recessive or dominant by interpreting the inheritance pedigree
- Explain the principle of epistasis and compare it to other inheritance principles such as co-dominance and incomplete dominance
- Differentiate between the mutational events at the genetic level that lead to phenotypic biochemical changes
- Explain what a base substitution, base deletion, DNA insertions, DNA sequence deletions and alterations to non-coding regions are
- Explain the effects of these mutations on gene function and their modes of inheritance
Independent Assortment & Linkage
- what is the $F_1$ and $F_2$ of crossing purebred 2 trait parents?
- what is Mendel's law of independent assortment?
- what is an exception to this law?
- how does meiotic recombination affect what alleles are inherited?
- what is the effect of linkage?
- what becomes less likely the closer 2 genes are?
- what is the probability of crossing over between 2 genes is proportional to?
- what unit is used to measure recombination distance?
- how do you calculate recombination distance?