Learning Objectives
- Outline the ion fluxes involved in the phases of the AP in cardiomyocyte and nodal cells
- Explain processes involved in Na+ channel activation and refractory periods in cardiomyocytes
- Outline the cellular and ionic mechanisms responsible for the 3 major types of arrhythmias
- Describe the Singh Vaughan Williams system for classifying antiarrhythmic drugs
- Describe the cellular mechanism of action of the different classes of antiarrhythmic drugs
- Explain the major adverse effects and important interactions and contraindications associated with antiarrhythmic drugs
- Outline the main classes of antiarrhythmic drugs used for the treatment of atrial fibrillation and supraventricular tachycardias
Antiarrhythmic Drugs
- what are the 3 main causes of arrhythmias?
- what are the goals of arrhythmia treatment?
- in general, how do antiarrhythmics work?
- what are the 4 classes of the Singh Vaughan Williams system?
- what 3 antiarrhythmics are not classified this way?
Sodium Channel Blockers
- mechanism of action?
- indications?
Beta Blockers