Learning Objectives

• Describe the role of leukocytes in tissue injury
• Outline how acute inflammation is terminated, and the outcomes
• Describe the main features, including cells and mediators involved in chronic inflammation, and compare and contrast with acute inflammation
• Describe the role of macrophages leukocytes and other cells, and their interactions, in chronic inflammation
• Identify and describe the main features of granulomatous inflammation
• Outline the systemic effects of inflammation and their basic mechanisms
• Outline the processes of tissue repair, including the cell types and main growth factors involved
• Compare and contrast regeneration and scar formation in terms of type of injury, proliferative capacity of tissues involved, cellular response, outcomes/ examples of each
• Outline the role of each of the components of the extracellular matrix in repair
• Describe the steps in scar formation
• Describe the local and systemic factors that influence wound healing

Acute Inflammation

• what are 3 circumstances where leukocytes cause tissue injury?
• what is the acute phase reaction? features?
• what are some blood markers of an acute phase reaction?
• what processes occur to terminate acute inflammation?
• what are 3 general outcomes of acute inflammation?

Chronic Inflammation